a Case Study - Cholera A 25 year old woman is brought into a clinic in Bangladesh during the monsoon season. She is almo

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A Case Study Cholera A 25 Year Old Woman Is Brought Into A Clinic In Bangladesh During The Monsoon Season She Is Almo 1 (72.88 KiB) Viewed 65 times

a Case Study - Cholera A 25 year old woman is brought into a clinic in Bangladesh during the monsoon season. She is almost comatose, her pulse is weak and she is experiencing tachycardia. She has severe diarrhea, and is producing watery stool at a rate of 950 ml/hr. Her skin appears shriveled, and when a fold of skin is pinched it remains so for several minutes. Microscopic examination of the patient's stool reveals the presence of a large number of Vibrio cholerae bacteria. The patient cannot drink, so intravenous isotonic NaCl is administered. When the patient is conscious, she is given anpral rehydration solution to drink. It contains NaCl, KCI, NaHCO3 and glucose. After 5 days site is sufficiently recovered to leave the hospital. 1. How did she most likely encounter the bacteria? 2. Why does she exhibit weak pulse and tachycardia? Why is she almost comatose? 3. How did the cholera toxin enter the cells and how did it affect intracellular signal transduction pathways and membrane transport. 4. How do intravenous fluids immediately improve the patient's condition? Why isotonic Naci? 5. What is the rationale for the ingredients in the oral rehydration solution? 6. Why does the patient recover in 5 days with this treatment and without antibiotics?