Sample Label Lane Sample/Family Member Genotype A 1 Standard DNA Marker none B 2 Normal (ff) ff C 3 FH Control (FF) FF D

[answerhappygod]

Sample Label
Lane
Sample/Family Member
Genotype
A
1
Standard DNA Marker
none
B
2
Normal (ff)
ff
C
3
FH Control (FF)
FF
D
4
Changman
ff
E
5
Jia
Ff
F
6
Aki
ff
G
7
Justin
Ff
H
8
Amy
FF
Question:
You are going to complete a final report to be shared
with the Kim Family. Divide your paper into the following
sections. Be sure to pay attention and include everything asked for
in each section.
Section One: What is FH?
Genetic mutation
It increases the blood levels of low-density
lipoprotein (LDL) cholesterol
Is FH caused by a chromosomal abnormality or a genetic
mutation?
How does having FH impact the body?
How can you describe and demonstrate the pattern of
inheritance?
Write a paragraph or two that explains to Aki, in simple
terms, what FH is and how it might affect members of his family who
have the LDLR gene mutation that causes FH. Include average
cholesterol levels for individuals with the mutated LDLR gene and
discuss the dangers of high cholesterol.
Section Two: Complete Lab Testing
What members of the Kim family have FH? Deduce the
genotype of members of the Kim family who were not tested (Akari
and Junseo).
Explain the likelihood of future generations having FH
for each member tested? (Use Punnett square to help you give a one
sentence risk assessment to each family member)
Complete the pedigree for familial
hypercholesterolemia in Aki’s family. Provide a key for the
pedigree.
(Attach your 2.2.6 Practice to your summative when you
turn it in)
Section Three: Final Report to Family
Write a brief statement identifying which of the family
members are most at risk for having high cholesterol.
Describe treatment options for family members with FH.
Be sure to include the class of medications called
statins.
How can lifestyle modifications help manage the
condition?