BACE1 gene is a target of the miR-425 microRNA. When miR-425 is expressed in cultured cells, BACE1 protein levels are re

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Bace1 Gene Is A Target Of The Mir 425 Microrna When Mir 425 Is Expressed In Cultured Cells Bace1 Protein Levels Are Re 1 (31.5 KiB) Viewed 70 times

BACE1 gene is a target of the miR-425 microRNA. When miR-425 is expressed in cultured cells, BACE1 protein levels are reduced. If you treat your cells (which do express miR-425) with an inhibitor of dicer, BACE1 protein levels will be higher than in untreated cells because the normal function of dicer is to remove the terminal loop fre$. If you also treated the worms with miR-425 ✓ Select) pre-miRNA, the BACE1 protein levels woul be higher than in untreated cells would be lower than in untreated cells would be about the same as in untreated cells