- 3 10 Pts Several Different Mutated Serca Pump Proteins Are Being Characterized In The Laboratory Each Protein Is Una 1 (48.13 KiB) Viewed 219 times
3. (10 pts) Several different mutated SERCA pump proteins are being characterized in the laboratory. Each protein is una
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3. (10 pts) Several different mutated SERCA pump proteins are being characterized in the laboratory. Each protein is una
3. (10 pts) Several different mutated SERCA pump proteins are being characterized in the laboratory. Each protein is unable to transport Ca?" because of a single defect in one of the domains. Read the descriptions of the characteristics of each variant protein and determine which domain is defective in each case. In each experiment, 1 nM (1 x 10'M) protein was used. The lowest amount of ADP or P that can be detected is 100 nM. Phosphorylated protein can be detected by using radioactive ATP. Choose your answers from: A domain N domain P domain S, T (transmembrane) domains Variant 1: No Ca? is transported, and no ADP can be detected, but the protein becomes labeled with phosphate if radioactive ATP is used. defective domain: Variant 2: ADP and P are produced by the protein, but no Ca’ is transported. defective domain: Variant 3: No Cais transported, ATP does not bind to the protein, and no phosphorylated protein can be detected defective domain: Variant 4: No Como is transported, and ATP binds to the protein, but no phosphorylated protein can be detected defective domain:
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