- Question 18 In Your Attempts To Identify The Genetic Basis Of Crohn S Disease In Humans You Have Dna Samples From Three 1 (150.55 KiB) Viewed 346 times
QUESTION 18 In your attempts to identify the genetic basis of Crohn's disease in humans, you have DNA samples from three large unrelated families in which individuals with varying severity of the disease are found. From your analysis of various SNPs, you find that the same four unlinked loci consistently show a correlation with the most severe cases from all three families. Based on your observations, which of the following hypotheses best describes the genetic control of Crohn's disease? Crohn's disease is controlled by polygenic (or quantitative) traits Crohn's disease is controlled by a single X-linked recessive trait Different genes regulate the disease in different families Crohn's disease is controlled by a single autosomal dominant trait Crohn's disease is the result of phenocopy by the environment QUESTION 19 Much recent evidence supports the hypothesis that modern humans originated in Africa and then spread out into Europe and Asia. Which of the following findings is/are consistent with this hypothesis? Neanderthal sequences are found in modern humans populations from Europe and Asia, but not Africa. Genetic diversity is greatest in African humans compared to other human populations. O Lighter pigmentation, seen in European and Asian populations compared to African populations, appears to have evolved from African populations via partially independent routes as humans expanded into Europe and Asia. All of the above