The pedigrees below here were obtained with three unrelated families whose members express the same completely penetrant

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The Pedigrees Below Here Were Obtained With Three Unrelated Families Whose Members Express The Same Completely Penetrant 1 (224.53 KiB) Viewed 183 times

The pedigrees below here were obtained with three unrelated families whose members express the same completely penetrant disease caused by an autosomal dominant mutation that is linked at a distance of 10 CM from a marker locus with three alleles numbered 1, 2, and 3. The marker alleles present within each living person's genotype are indicated below the pedigree symbol. The phenotypes of the newly born labeled individuals—A, B, C, and D—are unknown. 13 22 13 22 12 32 12 32 12 32 ? 12 ? 32 ? 32 ? 32 12 12 A B с D What is the probability of individual C NOT showing the disease? d 0.45 O O 0 O 1 0.1 Ο Ο 0.9

In E. coli and other bacteria, CRP activates transcription of several operons in response to glucose starvation. You hypothesize that many other genes are also regulated by CRP as part of a global transcriptional response to glucose starvation. Which of the following experiments would be useful for identifying most if not all of the genes regulated by CRP? RNA-seq comparing WT and crp mutant E. coli grown in low glucose DNA foot-printing of the lac promoter to see where CRP binds Northern blot analysis of the crp mRNA comparing E. coli grown with and without glucose Genomic sequencing of WT and crp mutant E. coli grown in low glucose O FISH of the crp gene QUESTION 3 Results from genome wide transcript profiling using RNA-seq revealed that from the over 6000 genes encoded by the yeast genome, approximately 800 yeast genes are regulated transcriptionally in a cell cycle specific manner. After looking through this list of 800 cell cycle regulated genes you notice that several genes are missing from the list that you know are required at only a specific phase of the cell cycle. Which statement(s) could explain how a gene's transcript could be present throughout the cell cycle, but produce a protein active only at one specific phase? a protein might be present throughout the cell cycle, but its function is only required at one specific phase of the cell cycle a protein could have its activity regulated by post-translational modifications such as phosphorylation a protein might be stable at only one phase of the cell cycle