Question 1: Of Cancer and Blood Vessels (25 points total) 1. Your clinical care team is determining the effect of chemot

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Question 1 Of Cancer And Blood Vessels 25 Points Total 1 Your Clinical Care Team Is Determining The Effect Of Chemot 1 (46.25 KiB) Viewed 151 times

Question 1: Of Cancer and Blood Vessels (25 points total) 1. Your clinical care team is determining the effect of chemotherapy A effects on angiogenesis and insulin blood plasma levels, and ATP/ADP ratio in ascending limb of nephron. Evaluate the data below. Patient Treatment of Number of Insulin levels in ATP/ADP ratio in Chemotherapy angiogenic blood blood plasma ascending limb of A vessels at brain (UM) mammalian tumor site Average #nephron standard deviation No treatment 30+ 5 M 3.5 100 mg 22 5+5 um 02 с 250 10+5 um 03 D 10mg 120 15 + 5 M 33 Note: ***indiates statistically significant difference in insulin plasma levels compared to patient A B 127 40 mg Question 1, continued Part IC: Your research team wants to test the following hypothesis: Addition of competitive inhibitor III is required for blocking the function of orclin dependent kinase during G/Sphase transition in tumor cells. Available Materials to your rescarch team: 1.) An inactive inhibitor 111 2.) Competitive inhibitor 111 (binds to active site of 111 enzyme) at different concentration micromolar (UM) doses. 3.) Normal skin epithelial cells 4.) Tumor skin cells How would you design your experiment using the available materials above? Include appropriate control and experimental groups, and write down two possible results from your experimental plan. (10 points; 5 points for appropriate controls and experimental groups; 5 points for two possible results from experimental plan).