Antibiotic resistance workshop 1. Kanamycin is an aminoglycoside. No longer used because resistant bacteria can phosphor

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Antibiotic resistance workshop 1. Kanamycin is an aminoglycoside. No longer used because resistant bacteria can phosphor

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Antibiotic Resistance Workshop 1 Kanamycin Is An Aminoglycoside No Longer Used Because Resistant Bacteria Can Phosphor 1
Antibiotic Resistance Workshop 1 Kanamycin Is An Aminoglycoside No Longer Used Because Resistant Bacteria Can Phosphor 1 (33.33 KiB) Viewed 119 times
Antibiotic resistance workshop 1. Kanamycin is an aminoglycoside. No longer used because resistant bacteria can phosphorylate one of the hydroxyl groups present -NH2 HO HO -NH2 HO HO HyN D HO- Ho HO HEN HO Phosphorylation HO -NH2 Kanamycin OH -NH2 OH Inactive NH2 OH ΝΗΣ OH -OH OH The gem diol on the carbon where the blue OH group is phosphorylated has been shown to kick out the phosphate group when it is formed. a) Show a mechanism for this step b) Show what Kanamycin derivative could be developed to overcome this inactivation and confer activity against resistant bacteria
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