(e) The partially protected dinucleotide below was synthesized by the phosphodiester approach. Suggest a mechanism for i
Posted: Tue May 17, 2022 9:02 am
(e) The partially protected dinucleotide below was synthesized by the phosphodiester approach. Suggest a mechanism for its formation. (25) DMTIO B DMTVO B HO-P B MS-CI, Py + 0- B OH OAC OAC DMTr, 4,4'-Dimethoxytrityl MS-CI, 2,4,6-Trimethylbenzenesulfonyl chloride Py, Pyridine B = nucleobase
(e) The partially protected dinucleotide below was synthesized by the phosphodiester approach. Suggest a mechanism for its formation. (25) DMTIO B DMTVO B HO-P B MS-CI, Py + 0- B OH OAC OAC DMTr, 4,4'-Dimethoxytrityl MS-CI, 2,4,6-Trimethylbenzenesulfonyl chloride Py, Pyridine B = nucleobase
(e) The partially protected dinucleotide below was synthesized by the phosphodiester approach. Suggest a mechanism for its formation. (25) DMTIO B DMTVO B HO-P B MS-CI, Py + 0- B OH OAC OAC DMTr, 4,4'-Dimethoxytrityl MS-CI, 2,4,6-Trimethylbenzenesulfonyl chloride Py, Pyridine B = nucleobase