- 8 The Drug Aspirin Acetylsalicylic Acid Operates By Acylation Of The Side Chain Alcohol Of Serine 530 On The Enzyme C 1 (75.89 KiB) Viewed 13 times
8) The drug aspirin (acetylsalicylic acid) operates by acylation of the side-chain alcohol of serine-530 on the enzyme c
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8) The drug aspirin (acetylsalicylic acid) operates by acylation of the side-chain alcohol of serine-530 on the enzyme c
8) The drug aspirin (acetylsalicylic acid) operates by acylation of the side-chain alcohol of serine-530 on the enzyme cyclooxygenase 2 (COX2), inhibiting the production of inflammatory signaling molecules. O ОН HO OH COX2 Ser-530 COX2 Ser-530 OH Using the standard, curved-arrow formalism, provide a mechanism for this transformation under acidic conditions. (10 points) Draw the most likely protonation state of acetylsalicylic acid at pH 7. Using a convincing structural drawing, explain why this reaction proceeds spontaneously without added acid or base. (5 points)