Problem 13. We have discussed in class that amines are Lewis bases and numerous amino- containing bioactive molecules (s

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Problem 13 We Have Discussed In Class That Amines Are Lewis Bases And Numerous Amino Containing Bioactive Molecules S 1 (53.53 KiB) Viewed 60 times

Problem 13. We have discussed in class that amines are Lewis bases and numerous amino- containing bioactive molecules (say, alkaloids) exist either as free bases or as salts upon reaction with acids. An example is Albuterol, a medication used to treat asthma attacks Albuterol is administered as albuterol sulfate. What is the reason for doing this? НО. HO 1/2 SO HO HO OH OH Albuterol Albuterol Sulfate a) Just marketing: a free base and an ammonium salt of a drug always have identical properties b) The ammonium salt of the drug is soluble in hexane and it can be injected into the patient as a hexane solution c) The ammonium salt of the drug is water soluble and it can be administered through a nebulizer d) The ammonium salt of the drug tastes better Part III. Reactions 17 problems Problem 14. From quiz What is the major organic product obtained from the following sequence of reactions? CH 2nco) Cul Br E, (d) (c) (b) " AA (a) Problem 15. Select the reagent and conditions necessary to carry out the last step in the synthesis of this penicillin analog. HH ня HO HO Br COOR COOR Pd[PPh34 THF (b) -B(OH)2 Culi (a) then H30* NC NC Pd[PPh3l4 2 -Br AICI: (d) (c) NC . NC