- 6 Glycogen Synthase Kinase 3 Beta Gsk 3b Is A Serine Threonine Kinase For Its Ability To Regulate Glycogen Synthesis 1 (84.14 KiB) Viewed 37 times
6. Glycogen synthase kinase 3 beta (GSK-3B) is a serine-threonine kinase for its ability to regulate glycogen synthesis.
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6. Glycogen synthase kinase 3 beta (GSK-3B) is a serine-threonine kinase for its ability to regulate glycogen synthesis.
6. Glycogen synthase kinase 3 beta (GSK-3B) is a serine-threonine kinase for its ability to regulate glycogen synthesis. In addition, it has been reported that GSK-3B plays important roles in many intracellular pathways and numerous pathologies, such as Alzheimer's disease and cancer. Inhibitors have been developed to modulate GSK-3B activity and used as therapies. The kinetics of the enzyme (GSK-3B) with and without its inhibitor is shown in the plot below. 1/v (sec/uM) -- 3 3 1/[S] (1/uM) a) Which line indicate the condition with inhibitor, line A or line B? b) What is the type of this inhibitor? Explain. to better c) Determine Vmax and Km for this enzyme in the inhibited state. Be sure to include the units.
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