Case 4: Obesity A 19-year-old woman sought medical help because she was 30 kg Overweight. Most of her excess weight was

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Case 4: Obesity
A 19-year-old woman sought medical help because she was 30
kg
Overweight. Most of her excess weight was in the form of
adipose
Tissue. Medical history revealed that her diet was extremely
poor.
Much of her caloric intake was carbohydrate-candy. Cookies.
Cake.
Soft drinks and beer; her dietary fat intake was actually quite
moderate.
BIOCHEMICAL QUESTIONS
1. How is it possible to form excessive amounts
of triglyceride in the body if a diet contains
predominantly carbohydrates?
2. How does acetyl CoA generated inside the mitochondria
reach the cytoplasm for use by the fatty acid biosynthetic
pathway?
3. Why is bicarbonate required for fatty acid synthesis?
4. How are sulfhydryl groups involved in the action
of fatty acid synthase?
5. How might the carbohydrate ingest by this patient supply
the NADPH needed for fatty acid biosynthesis?