QUESTION 2 Answer the following questions given that compound B is an inhibitor of a-chymotrypsin. Ph 1 R? R2 Br Br Br N

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Question 2 Answer The Following Questions Given That Compound B Is An Inhibitor Of A Chymotrypsin Ph 1 R R2 Br Br Br N 1 (70.16 KiB) Viewed 75 times

QUESTION 2 Answer the following questions given that compound B is an inhibitor of a-chymotrypsin. Ph 1 R? R2 Br Br Br NH2 0 O Ph3P N N R3 R3 R1 CONHPH CONHOh R1 CONHPH E F B с (a) Depict how B relates to a natural substrate for a-chymotrypsin. [2 marks] (b) Discuss the likely mechanism by which B would inhibit a-chymotrypsin. [5 marks] (C) A library of structures of type B is represented by C, which contains three sites of structural variability (designated R1, R2 and R3). A retrosynthesis of C to give building blocks D, E and F is shown. Describe (in principle only) how you would use solution-based split synthesis to prepare a library of C using 5 examples of each of D, E and F. Reaction mechanisms are not required. [3 marks] (d) How many different examples of C would be obtained from the experiment outlined in part (c)? Explain your answer. [2 marks]