3. Suppose that you designed a study to examine the association between cholesterol levels and the risk of stroke. Your

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3 Suppose That You Designed A Study To Examine The Association Between Cholesterol Levels And The Risk Of Stroke Your 1 (73.36 KiB) Viewed 87 times

3. Suppose that you designed a study to examine the association between cholesterol levels and the risk of stroke. Your study population was a group of 3,700 randomly selected men and women in whom you measure total cholesterol level at study baseline. You defined a level of < 200 mg/dl as low cholesterol, 200-250 mg/dl as moderately high, and > 250 as high cholesterol. Study investigators informed participants of their baseline cholesterol levels. After 20 years, 30/1,500 subjects with low cholesterol suffer strokes, 25/1,000 with moderately high cholesterol suffer strokes, and 60/1,200 with high cholesterol suffer strokes. Assume denominators are actual number of subjects in three cholesterol level categories. Also assume that the low-cholesterol group is the unexposed group. a. What is the relative risk of stroke among those with high, as compared to low, levels of cholesterol? b. What is the relative risk of stroke among those with moderately high, as compared to low, levels of cholesterol? c. What is the relative risk of stroke among those with high or moderately high, as compared to low, levels of cholesterol? d. What is the PAR for stroke that is attributable to high cholesterol in this population if we assume the prevalence of high cholesterol in the population is 30 percent? e. What is the attributable risk (risk or rate difference) of high versus low cholesterol?