Answer Happy

The following table from a 2001 JAMA paper by Pradhan and
colleagues (JAMA 2001; 286:327-334) summarizes findings from a
nested case-control study. The purpose of this study was to
determine if elevated levels of inflammatory markers interleukin 6
(IL6) and C-reactive protein (CRP) are associated with the
development of Type-2 Diabetes Mellitus (T2DM) in healthy
middle-aged women.
Table 2. Crude and Adjusted Relative Risks of Type 2 Diabetes Mellitus, According to Baseline Plasma Concentration of Interleukin 6 and C-Reactive Protein* Quartile of Interleukin 6, Median (Interquartile Range), pg/mL Quartile of C-Reactive Protein, Median (Interquartile Range), mg/dL 1 3 4 1 2 0.698 1.133 1.646 2.709 (<0.909) (0.91-1.382) (1.383-2.050) (>2.050) 2 3 P for 0.050 0.170 0.435 0.930 Trend (<0.10) (0.10-0.26) (0.27-0.61) (>0.61) P for Trend Crude analysis 1.0 2.5 (1.1-5.6) 4.1 (2.0-8.4) 7.5 (3.7-15.4) <.001 1.0 .02 2.2 (0.8-6.0) 8.7 (3.6-21.0) 15.7 (6.5-37.9) <.001 .13 <.001 <.001 <.001 <.001 Relative risk (95% CI) 1.0 .008 1.0 1.8 (0.7-4.4) 1.9 (0.8-4.2) 2.9 (1.3-6.7) .19 1.2 (0.4-3.5) 4.1 (1.6-10.6) 4.4 (1.7-11.5) <.001 .73 .002 P value .12 .01 .004 Adjusted for all risk factorst Relative risk (95% Cl) 1.0 .07 1.0 1.4 (0.6-3.7) 1.3 (0.6-3.1) 2.3 (0.9-5.6) .47 51 1.3 (0.4-4.1) 4.1 (1.5-11.5) 4.2 (1.5-12.0) .001 .61 .007 .007 .08 P value *Limited to subjects with hemoglobin A₁ of 6.5% or less: 188 cases, 362 controls. Cl indicates confidence interval; BMI, body mass index. †Matched on age and fasting status, controlled for BMI, family history of diabetes, smoking, physical activity, alcohol consumption, and hormone replacement therapy. Relative risk (95% CI) P value BMI-adjusted analysis