A 45 year old female with a known diagnosis of diabetes mellitus visited her physician because of difficult and painful

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A 45 Year Old Female With A Known Diagnosis Of Diabetes Mellitus Visited Her Physician Because Of Difficult And Painful 1 (33.82 KiB) Viewed 34 times

A 45 year old female with a known diagnosis of diabetes mellitus visited her physician because of difficult and painful urination. Physical examination revealed that the patient had a slightly elevated temperature but no other abnormalities. A complete blood count, urinalysis, and urine culture were ordered. Lab data The patient's hemoglobin and hematocrit were normal. However, the total leukocyte count 28.5 x 10', with the following leukocyte differential results: neutrophils 79%, bands 10%, eos 2%, lymphs 9% Most of the segmented neutrophils display dark, coarse granulation. Many of the neutrophils were also vacuolated. The patient's urine had an elevated concentration of protein, increased number of leukocytes and many bacteria. The urine culture had a heavy growth of a gram-negative rod Pseudomonas species. Questions 1. What is the dark, coarse granulation in the neutrophils? 2.Does the condition alter the phagocytic effectiveness of the leukocytes? 3. What is the most probable explanation of the patient's elevated leukocyte count?