Which of the following is true regarding extent of absorption of drugs?

[answerhappygod]

Which of the following is true regarding extent of absorption of drugs?

A. After oral ingestion of drugs, the absorption of drug may be incomplete
B. Drugs which are too lipophilic cannot cross the lipid cell membrane
C. Drugs which are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell
D. P-glycoprotein is an efflux transporter which is present in the enterocytes and it enhances the absorption of drug E. Grape juice activates P-glycoprotein leading to substantial inhibition of absorption of drugs