Problem 2: Oxygen transport and carbon monoxide poisoning Hemoglobin molecules are responsible for transporting any in t

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Problem 2 Oxygen Transport And Carbon Monoxide Poisoning Hemoglobin Molecules Are Responsible For Transporting Any In T 1 (83.95 KiB) Viewed 38 times

Problem 2 Oxygen Transport And Carbon Monoxide Poisoning Hemoglobin Molecules Are Responsible For Transporting Any In T 2 (36.95 KiB) Viewed 38 times

Problem 2: Oxygen transport and carbon monoxide poisoning Hemoglobin molecules are responsible for transporting any in the blood. A single hemoglobin molecule has four absorption sites consisting of Fees, but we will simplify things by only considering one site Fe A. First consider a single absorption site which has four O, Solecules nearby (as in close enough to bind to the site). Take the energy of an empty site to be 0. while the energy of the oxygen-bound state is -1.6 x 10-20 a What are the possible states, and what are their multiplicities! b. What is the ratio of probabilities of finding the absorption site to be occupied to unoccupied, Take the temperature of the human body to be 310 K. c. What is the absolute probability to find an absorption site in the oxygen-bound state in the above conditions? Express your a wer as a percentage Unfortunately, carbon monoxide was not a common molecule when hemoglobin evolved, and the binding site does not distinguish between O, and CO. When carbomooride is present, it can bind to some of the available hemoglobin sites, which prevents the hemoglobin from carrying oxygen Fe B. CO binds at an absorption site with energy Eco -4,05 x 10-20. Suppose there is a lo 100 ratio of CO 1o O present in the wood. For simplicity's sake assume there are now 100 O, molecules available to bind. a What are the possible states now, and what are the multiplicite b. What is the ratio of probability to find the absorption site occupied by CO compared to 0-2

4 of 5 What is the ratio of probability to find the absorption site occupied by to 0,2 compared c. Under these conditions, what is the new absolute probability to find an absorption site occupied by an O, molecule? Express your answer as a percentage d. Compare your answers to parts A.c and B.c, and then explain why carbon monoxide alarms are common in many houses C Carbon monoxide poisoning is usually treated by putting patients in a hyberbaric oxygen chamber, where patients breathe pure O, at 2-3 atmospheres. a. Qualitatively explain how this would help treat CO poisoning b. With the same amount of CO in your blood, but 2-3 times as much Os, compute the new probability of an absorption site being occupied by an O molecule.