Which of the following may be a reason that a drug has a very low Vd? Group of answer choices Much of the drug has been

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Which of the following may be a reason that a drug has a verylow Vd?
Group of answer choices
Much of the drug has been diffused into bodies tissues.
There is a relative high degree of binding to plasmaproteins.
There is high solubility in lipids.
Much of drug has bound to target proteins outside of theplasma.