Duchenne's Muscular Dystrophy (DMD) 18. A 23-year-old woman (individual II-1 in the pedigree) seeks genetic counseling b

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Duchenne S Muscular Dystrophy Dmd 18 A 23 Year Old Woman Individual Ii 1 In The Pedigree Seeks Genetic Counseling B 1 (110.65 KiB) Viewed 43 times

Duchenne's Muscular Dystrophy (DMD) 18. A 23-year-old woman (individual II-1 in the pedigree) seeks genetic counseling because her brother has Duchenne muscular dystrophy (DMD). Her brother (II-2) has a deletion in the DMD gene. Although her mother (I-2) does not have the deletion, individual II-1 is told that her risk for carrying the DMD gene is greater than that of the general population. Which of the following best explains this increased risk? A) De novo gene mutation B) Locus heterogeneity for DMD C) Maternal germline mosaicism D) Promoter mutation E) Suspected parental consanguinity F) X inactivation