Problem 9.6 Triiodothyronine (T3) binds tightly to the wild-type thyroid hormone receptor, forming a stabilizing hydroge

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Problem 9.6 Triiodothyronine (T3) binds tightly to the wild-type thyroid hormone receptor, forming a stabilizing hydroge

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Problem 9 6 Triiodothyronine T3 Binds Tightly To The Wild Type Thyroid Hormone Receptor Forming A Stabilizing Hydroge 1
Problem 9 6 Triiodothyronine T3 Binds Tightly To The Wild Type Thyroid Hormone Receptor Forming A Stabilizing Hydroge 1 (53.49 KiB) Viewed 37 times
Problem 9.6 Triiodothyronine (T3) binds tightly to the wild-type thyroid hormone receptor, forming a stabilizing hydrogen bond with His435 (H435) in the ligand-binding site. An orthogonal, non-metabolizable analog (QH2) was designed to be inactive against the natural receptor, but highly active against a compensatory mutant. Which thyroid receptor mutant would be most likely to respond to QH2: H435A, H435F, H435G, H435K, H435W, or H435R? QH2 H435 Tg NHS 0 NH NS O
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