1. Ephedrine is a naturally occurring drug useful in the treatment of asthma. [2 marks] a. Classify ephedrine as acidic,
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1. Ephedrine is a naturally occurring drug useful in the treatment of asthma. [2 marks] a. Classify ephedrine as acidic,
1. Ephedrine is a naturally occurring drug useful in the treatment of asthma. [2 marks] a. Classify ephedrine as acidic, basic or neutral. b. Using your answer of part (a) as a guide suggests a simple way in which the water solubility of the drug could be increased. H OH CHE 'N-CH3 H Ephedrine, pka = 9.6 2. Calculate the percentage of a dose of pentobarbital that will be ionized at plasma pH (7.4). [2 marks] HN NH Pentobarbital, pKa= 8.0
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