Elaborate your thought
- Can This Procedure Be Scaled Up For Industrial Manufacturing Elaborate Your Thought 1 (179.95 KiB) Viewed 20 times
Can this procedure be scaled up for industrial manufacturing? Elaborate your thought
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Can this procedure be scaled up for industrial manufacturing? Elaborate your thought
Can this procedure be scaled up for industrial manufacturing?
Elaborate your thought
IV. PROCEDURE 1. Add three crushed Vivarin tablets to 100 mL of water in a 250-ml Erlenmeyer flask. Then boil the mixture for 10 min to ensure solution of the caffeine. The binder in the tablets will remain in suspension. 2. Filter off the binder by suction filtration. Save the liquid. 3. Cool the extract to room temperature, transfer it to a 250 mL separatory funnel, and extract the aqueous solution three times with 20-ml portions of methylene chloride. Do not shake the layers vigorously; use a swirling motion so as not to form an emulsion. 4. Combine the methylene chloride extracts and evaporate the extract to dryness on the steam bath (HOOD). Do not heat the residue any longer than necessary to evaporate the solvent. The residue that remains after evaporation of the solvent is crude caffeine; some mint smell will be evident. The caffeine may be purified by recrystallization as described below. PURIFICATION PROCEDURE 1. Transfer the crude caffeine to a clean 50-ml beaker, add 5 ml benzene, and heat on a hot water bath to dissolve the caffeine. 2. Remove the beaker from the heat source, add 10 ml petroleum ether (boiling range 60- 90°C), and allow the caffeine to crystallize. 3. Collect the product by suction filtration, wash it with 1 ml petroleum ether, allow it to air-dry, and determine its melting point.
Elaborate your thought
IV. PROCEDURE 1. Add three crushed Vivarin tablets to 100 mL of water in a 250-ml Erlenmeyer flask. Then boil the mixture for 10 min to ensure solution of the caffeine. The binder in the tablets will remain in suspension. 2. Filter off the binder by suction filtration. Save the liquid. 3. Cool the extract to room temperature, transfer it to a 250 mL separatory funnel, and extract the aqueous solution three times with 20-ml portions of methylene chloride. Do not shake the layers vigorously; use a swirling motion so as not to form an emulsion. 4. Combine the methylene chloride extracts and evaporate the extract to dryness on the steam bath (HOOD). Do not heat the residue any longer than necessary to evaporate the solvent. The residue that remains after evaporation of the solvent is crude caffeine; some mint smell will be evident. The caffeine may be purified by recrystallization as described below. PURIFICATION PROCEDURE 1. Transfer the crude caffeine to a clean 50-ml beaker, add 5 ml benzene, and heat on a hot water bath to dissolve the caffeine. 2. Remove the beaker from the heat source, add 10 ml petroleum ether (boiling range 60- 90°C), and allow the caffeine to crystallize. 3. Collect the product by suction filtration, wash it with 1 ml petroleum ether, allow it to air-dry, and determine its melting point.
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