Symbicort Rapihaler 100/3 is a metered dose inhaler, indicated for management of asthma or chronic obstructive pulmonary

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Symbicort Rapihaler 100/3 is a metered dose inhaler, indicated
for management of asthma or chronic obstructive pulmonary disease.
The National Asthma Council recommends using a spacer with
Symbicort Rabihaler.
1. Discuss how the use of the spacer with the inhaler may reduce
the side effect of throat thrush. Your answer should use the
relevant equation of deposition. (3 marks)
2. Controlling the particle size range
(within 2-5 micron) of drugs used in Symbicort Rapihaler is
critical to their successful deposition in the respiratory tissues.
Discuss this statement using the relevant equation of deposition.
(3 marks)
3. Outline the formulation components of
Symbicort Rapihaler 100/3 and the purpose of each component
included in this formulation. Your answer should explain how
ingredients can overcome the main physical instability of the
formulation. (4 marks)
4. If the formulation was prepared using two propellants
HFA-134a and HFA-227 (in a ratio of 0.25 moles of HFA-134a to 0.75
moles of HFA-227), calculate the total vapour pressure achieved in
the inhaler in kPa at 20 ºC. You need to show your calculations. [4
marks]
Note: you may refer to the vapour pressure of each
propellent (at 20 ºC) from the lecture notes or Table 37.1 in
chapter 37 (Pulmonary drug delivery) in Aulton’s pharmaceutics
(2018).