- May You Please Answer All The Questions Below 1 (32.14 KiB) Viewed 33 times
QUESTION 23 Which one of the following statements is true of cell-based assays? O a. Cannot distinguish between antagonists and agonists O b. Can only distinguish between different classes of drugs O c. Cannot give information about the specific binding site O d. Lead to "false negatives" resulting in lower number of hits O e. Provides very good target specificity 2.5 points Save Answer
QUESTION 24 Theoretically, which of these pharmacological approaches could cause hypertension as a side effect? Tick ALL that apply. This question has negative marking but the lowest possible mark for it is 0. a. An acetylcholinesterase inhibitor b. An alpha adrenoceptor agonist c. An alpha adrenoceptor antagonist Od. A beta adrenoceptor agonist e. A beta adrenoceptor antagonist Of. A noradrenaline reuptake inhibitor g. A muscarinic agonist Oh. A muscarinic antagonist 2.5 points Save Answer
QUESTION 25 The anti-hypertensive effects of beta-blockers are partly attributable to their effects at ✓ receptors. also have unwanted bronchoconstrictive effects via Muscle nicotinic CNS nicotinic Ganglion nicotinic M1 M2 M3 Alpha Beta-1 Beta-2 Beta-3 ✓ receptors, whereas they 2.5 points Save Answer
QUESTION 26 Theoretically, which of these pharmacological approaches could be used to treat asthma through their effects on bronchial smooth muscle contractility? Tick ALL that apply. This question has negative marking but the lowest possible mark for it is 0. a. An acetylcholinesterase inhibitor b. An acetylcholine reuptake inhibitor c. A beta adrenoceptor agonist d. A beta adrenoceptor antagonist ☐e. A muscarinic agonist f. A muscarinic antagonist Og. A tyrosine hydroxylase inhibitor 2.5 points Save Answer
QUESTION 28 Which one of the following describes the role of in vivo preclinical studies? O a. Determine how many participants are needed for phase I O b. Determine the pharmacokinetic profile of the drug candidate O c. Determine the receptor binding profile of the drug O d. Determine the CYP450 enzymes involved in metabolism Oe. Determine the bioavailability of the drug 2.5 points Save Answer
QUESTION 27 Complete the sentence below by selecting the appropriate words from the list below. The parasympathetic nervous system Stimulates Inhibits Acetylcholine Noradrenaline Muscle nicotinic CNS nicotinic Ganglion nicotinic M1 M2 M3 Alpha Beta-1 Beta-2 Beta-3 ✓ receptors. ✓saliva production through ✓acting at 2.5 points Save Answer
QUESTION 29 Complete the sentence below by selecting the appropriate words from the list below. The sympathetic nervous system ✓ uterine relaxation through ✓receptors. Stimulates Inhibits Acetylcholine Noradrenaline Muscle nicotinic CNS nicotinic Ganglion nicotinic M1 M2 M3 Alpha Beta-1 Beta-2 Beta-3 ✓ acting at 2.5 points Save Answer
QUESTION 30 The dose regimen in Phase II trials is based on which of the following? O a. The therapeutic windows of similar drugs O b. The time available to the participants O c. Pharmacokinetic parameters from Phase I O d. Pharmacodynamic parameters O e. The preparation of the drug 2.5 points Save Answer