- May Please Answer All The Below Questions 1 (38.71 KiB) Viewed 35 times
Which of these pharmacological approaches would enhance cholinergic transmission? Tick ALL that apply. This question has negative marking but the lowest possible mark for it is 0 . a. A choline uptake inhibitor b. A tyrosine uptake inhibitor c. A vesicular acetylcholine transport inhibitor d. An acetylcholine reuptake inhibitor e. An aldehyde dehydrogenase inhibitor f. A choline acetyltransferase inhibitor g. A tyrosine hydroxylase inhibitor h. An acetylcholinesterase inhibitor i. A monoamine oxidase inhibitor
Theoretically, which of the following classes of drugs could cause bronchoconstriction as a side effect? Tick ALL that apply. This question has negative marking but the lowest possible mark for it is 0 . a. An acetylcholinesterase inhibitor b. An acetylcholine reuptake inhibitor c. An aldehyde dehydrogenase inhibitor d. A beta adrenoceptor agonist e. A beta adrenoceptor antagonist f. A muscarinic agonist g. A muscarinic antagonist h. A noradrenaline reuptake inhibitor
In which of the following conditions might it be therapeutically useful to reduce cholinergic neurotransmission (at tissue target level)? Tick ALL that apply. This question has negative marking but the lowest possible mark for it is 0 . a. Asthma b. Constipation c. Difficulty urinating d. Excessive sweating e. Gastric ulcer f. Hypersalivation g. Painful gut spasms h. Painful neck spasms
Theoretically, which of these pharmacological approaches could be used to treat gut hypotonia through their effects on intestinal smooth muscle contractility? Tick ALL that apply. This question has negative marking but the lowest possible mark for it is 0. a. An alpha adrenoceptor agonist b. An alpha adrenoceptor antagonist c. A beta adrenoceptor agonist d. A beta adrenoceptor antagonist e. A muscarinic agonist f. A muscarinic antagonist g. An acetylcholine reuptake inhibitor h. A noradrenaline reuptake inhibitor
QUESTION 8 2.5 points "Blinding" refers to which one of the following; a. Not knowing which receptor is the target for a drug b. Not knowing the potential adverse reactions of a drug c. Not knowing which substance is active d. Not knowing the names of the people in the trial e. Not knowing the therapeutic window of a drug QUESTION 9 2.5 points Lipinski's "rule of 5 " relates to which of the following? a. Attributes of an oral drug b. The minimum therapeutic index c. The time taken from taking a dose to the effect d. The number of participants in the first stage of a clinical trial e. The number of stages a drug should go through during trials
Complete the sentence below by selecting the correct words from the list. Because of their indirect effects on receptors, indirectly-acting sympathomimetic amines are useful in the treatment of nasal congestion. However, they can cause unwanted effects such as increased heart rate through their indirect effects on receptors. Muscle nicotinic CNS nicotinic Ganglion nicotinic M1 M2 M3 Alpha Beta-1 Beta-2 Beta-3
The dose regimen used in Phase lla trials is based on which one of the following; a. Self-report of patients in phase I b. Pharmacokinetic profiles from phase I c. Pharmacodynamic profiles from phase I d. The lowest dose that could have an effect e. The optimal dose determined in phase I QUESTION 2 Hepatotoxicity is caused by which of the following? a. Metabolites causing oxidative damage b. Drugs causing oxidative damage c. Concentration of drugs in the portal vein d. Overactive CYP450 enzymes e. Covalent binding of drugs