This question follows the inheritance of an autosomal recessive lethal disease in which neurological deterioration occur

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This Question Follows The Inheritance Of An Autosomal Recessive Lethal Disease In Which Neurological Deterioration Occur 1 (76.8 KiB) Viewed 27 times

This question follows the inheritance of an autosomal recessive lethal disease in which neurological deterioration occurs early in life and people affected with the disorder die at a very. young age. The mutation responsible for the disease occurs in the gene Q which has two alleles Q and q. The disease is considered rare in the population but it occurs at a relatively high frequency in the descendants of the Moche civilization that inhabited Northern Peru. A man named Huascar whose paternal aunt had the disease is trying to determine the probability that he and his wife Isabel could have an affected child. His mother does not come from a high-risk population. His wife's brother died of the disease at an early age. Part A. (12 points) Draw the pedigree using the appropriate symbols/notation, including generations (1 point), individuals in the pedigree and the genotypes next to each symbol. ALL Carriers must have halfshaded symbol. Affected individuals must have full-shaded symbol. The pedigree should ONLY include the following and in the specified order: - Generation I: Huascar's paternal grandmother and grandfather ( 2 individuals). (2 points). - Generation II: Huascar's aunt, Huascar's parents, and Isabel's parents (5 individuals). (5 points). - Generation III: Huascar, Isabel and Isabel's brother (3 individuals). (3 points). - Generation IV: Huascar and Isabel's future child (1 individual, sex unspecified (use diamond shape), genotype unknown=?). (1 point). Part B. (8 points) Determine the probability that the couple's child will be affected (follow the order below). Show your calculations and Punnet squares (if needed) in order to calculate: A. Probability that Huascar's dad is a carrier. (2 pts) B. Probability that Huascar is a carrier (Hint: This can be found by the probability that Huascar's dad passes the recessive allele assuming he is a carrier). (2 pts) C. Probability that Isabel (Huascar's wife) is a carrier. (2 pts) D. Overall probability that Huascar and Isabel's child will be affected (Hint: You will need the probability that Huascar is a carrier, the probability that Isabel is a carrier, and the probability of each parent passing the affected allele). ( 2 pts)