- Answer Questions 13 Through 16 Using The Data Presented Below In Fig 3 And Based On The Information In The Table 1 1 (63.9 KiB) Viewed 44 times
- Answer Questions 13 Through 16 Using The Data Presented Below In Fig 3 And Based On The Information In The Table 1 2 (97.34 KiB) Viewed 44 times
Answer questions #13 through # 16 using the data presented below in Fig. 3, and based on the information in the Table 1 below and in your text. Note: A = adrenaline; NA= noradrenaline. Explain your answers. Table 1. Adrenoceptors 1adrenoceptors Nomenclature Other names Potency order Selective agonists Selective antagonists 2-adrenoceptors Nomenclature Other names Potency order Selective agonists Selective antagonists Coupling 1-adrenoceptors Nomenclature Other names Potency order Selective agonists Selective antagonists alpha 1A alpha 1a, alpha fe NA>adrenaline A61603 KMD3213 alpha 2A alpha 20 oxymetazoline BRL44408 Gvo alpha 1 adrenaline>NA adrenaline>NA NA-adrenaline Noradrenaline alpha 18 betatoxol alpha 1b adrenaline=NA AH11110A alpha 28 prazosin G alpha 2 adrenaline>NA procaterol ICI118551 alpha 1D alpha 1A/D adrenaline-NA BMY7378 alpha 2C Adrenaline>NA prazosin Gua alpha 3 atypical NA-adrenaline BRL37344 SR59230A alpha 4 NA>adrenaline bupranolol
Coupling A. Contraction of arterial strips Relaxation of bronchial smooth muscle Contraction of heart A Goo ΝΑ A Goo B. Slide 1, ΝΑ Gs or Gu NA NA NA+ propanolol I+ phenolamine NA+ phenolamine G A NA ryu Log concentration of catecholamine Log concentration of catecholamine NA+ phenolamine I+ propanolol 14. (2.5pts) Which receptor subtype(s) mediate(s) contraction of heart? Why? Answer based on the data presented above. (Figure 3 and the Table 1). Explain your answer. NA+ propanolol Figure 3. A. Dose-response curves (arbitrary scales) show relative potencies of three catecholamines on experimental muscle preparations. Changes in forces of contraction or relaxation are shown for each muscle tissue hung in separate tissue baths after addition of increasing concentrations of each catecholamine. B. Change in force of contraction or relaxation (arbitrary scale) of different tissues hung in separate tissue baths after addition of increasing concentrations of catecholamine in absence and presence of a fixed concentration of phentolamine or propanolol NA, noradrenaline; A, adrenaline; I, isoproterenol. 13. (2.5pts) Which receptor subtype(s) mediate(s) contraction of arterial strips? Why? Answer based on the data presented above. (Figure 3 and the Table 1). Explain your answer. 15. (2.5pts) Which receptor subtype(s) mediate(s) relaxation f bronchial smooth muscle? Why? Answer based on the data presented above. (Figure 3 and the Table 1). Explain your answer.