Which is TRUE regarding physical dependence on opioids: A. The withdrawal syndrome is frequently lethal B. It is the sam

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Which is TRUE regarding physical dependence on opioids:
A. The withdrawal syndrome is frequently lethal
B. It is the same thing as opioid addiction.
C. It will not occur if the opioid was prescribed by a doctor,
even when the opioid is administered over many months.
D. The withdrawal syndrome associated with opioid dependence
includes only intense craving for the drug and no physical
symptoms.
E. The withdrawal syndrome associated with opioid dependence
includes symptoms opposite in direction to the drug effects such as
pupil dilation, increased respiratory rate and diarrhea.