6. The table below lists pharmacokinetic parameters for doripenem in a healthy 70 kg individual: Volume of distribution

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6 The Table Below Lists Pharmacokinetic Parameters For Doripenem In A Healthy 70 Kg Individual Volume Of Distribution 1 (60.09 KiB) Viewed 48 times

6. The table below lists pharmacokinetic parameters for doripenem in a healthy 70 kg individual: Volume of distribution 16.8 L Total plasma clearance 15.9 L/h Plasma protein binding 8.1% Renal clearance 10.8 L/h Terminal half-life approx. 1 h The recommended dosing regimen for treatment of complicated urinary tract infection is 500 mg by IV infusion over 1 hour, every 8 hours, for 10 days. Using the data supplied, describe the disposition of doripenem over the course of the recommended regimen. (12 marks)