Perform structure activity identification (SAR) of alpidem that has the estructure. As in the example with other drug (i

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Perform structure activity identification (SAR) of alpidem that has the estructure.

Perform Structure Activity Identification Sar Of Alpidem That Has The Estructure As In The Example With Other Drug I 1 (3.9 KiB) Viewed 67 times

As in the example with other drug (it's just an online example)

Perform Structure Activity Identification Sar Of Alpidem That Has The Estructure As In The Example With Other Drug I 2 (41.67 KiB) Viewed 67 times

H₂C N N- -CH₂ -CI
SAR:- R₂ A FIZ B C P₂ -R₂ 1. In ring A an electron withdrawing group such as Cl, Br, No,,or CF3,CN at position 7. 2. A methyl group is attached to the nitrogen atom in 1 position in ring B. however substituents at position 1that are metabolically removed are still clinically useful. ex:-flurazepam,prazepam. 3. Replacement of the carbonyl function with two hydrogens in the second positiion gives medazepam less potent than diazepam. Replacement of one of the hydrogen with a OH on third position lowers activity on the one hand and aids elimination on the other. 4. Introduction of a carboxyl function in the third position increases the duration of action (clorazepate) and also favours formation of a water soluble salts.