10. A peptide has the following sequence: GSLRPEE The pka values of the peptide's side chains, terminal amino groups, an

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10 A Peptide Has The Following Sequence Gslrpee The Pka Values Of The Peptide S Side Chains Terminal Amino Groups An 1 (91.9 KiB) Viewed 30 times

10. A peptide has the following sequence: GSLRPEE The pka values of the peptide's side chains, terminal amino groups, and terminal carboxyl groups are provided in the table below. Amino acid Amino pK₁ Carboxyl pK₁ Side-chain pKa 9.60 2.34 4.25 1.82 6.00 2.38 2.21 2.34 2.36 2.17 1.99 glutamate histidine 9.17 tryptophan 9.39 serine 9.15 glycine leucine arginine proline 9.60 9.60 9.04 10.96 12.48 a. What is the net charge of the peptide at pH 3? List which group(s) carry a positive charge at this pH and which group(s) carry a negative charge at this pH. b. What is the net charge of the peptide at pH 8? List which group(s) carry a positive charge at this pH and which group(s) carry a negative charge at this pH. c. What is the net charge of the peptide at pH 11? List which group(s) carry a positive charge at this pH and which group(s) carry a negative charge at this pH.