CAN SOMEONE PLEASE HELP ME UNDERSTAND 1. Describe the difference between intertumoral heterogeneity and intratumoral het

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CAN SOMEONE PLEASE HELP ME UNDERSTAND 1. Describe the difference between intertumoral heterogeneity and intratumoral het

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CAN SOMEONE PLEASE HELP ME UNDERSTAND
1. Describe the difference between intertumoral heterogeneityand intratumoral heterogeneity seen in breast cancers. Giveexamples each.
2. What is meant by cell plasticity? How does it affect tumorheterogeneity?
3. How does cell plasticity allow intratumor cooperation betweensubclones?
4. Give an example of breast tumor cells cooperating withother cells in the host to promote progression.
5. How might cancer therapeutics change to accommodate tumorheterogeneity?
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