A 48-year-old man comes to the physician for a routing examination. He has a 6-month history of angina. His mother died

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A 48-year-old man comes to the physician for a routing examination. He has a 6-month history of angina. His mother died at the age of 56 years of coronary artery disease. Physical examination shows no abnormalities. Serum studies show a total cholesterol concentration of 450 mg/dl ; LDL-cholesterol concentration is increased, and HDL-cholesterol and triglyceride concentrations are within the reference range Following angiography and angioplasty of his circumflex coronary artery, treatment with a statin is begun Stalins are most likely to decrease this patient's serum cholesterol concentration by which of the following mechanisms?


A. Decreased synthesis of VLDL
B. Downregulation o f the LDL receptors
C. Downregulation of lecithin-cholesterol acetyltransferase(LCAT)
D. Increased synthesis of VLDL
E. Upregulation of the LDL receptors
F. Upregulation of lecithin-cholesterol acetyltransferase (LCAT)