A 5-year-old gir1 with AIDS develops a progressive generalized vesicular rash. High-dose antiviral therapy for the agent

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A 5-year-old gir1 with AIDS develops a progressive generalized vesicular rash. High-dose antiviral therapy for the agent

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A 5-year-old gir1 with AIDS develops a progressive generalized vesicular rash. High-dose antiviral therapy for the agent that causes these lesions is ineffective, and the lesions become hyperkeratotic. The genetic mutation responsible for the absence of susceptibifity to antiviral therapy involves the activity of which of the following enzymes?


A. DNA polymerase
B. Protease
C. Protein kinase
D. Reverse transcriptase
E. Ribonucleotide reductase
F. Thymidine kinase
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