A 62-year-old woman comes to the physician because of progressive bilateral lower abdominal pain and distention during t

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A 62-year-old woman comes to the physician because of progressive bilateral lower abdominal pain and distention during the past month. Pelvic examination shows an adnexal mass on the right. Pelvic ultrasonography shows a 6 x 6-cm mass in the right ovary with an internal echo pattern highly suggestive of ovarian cancer. Microscopic examination of peritoneal fluid obtained by paracentesis shows malignant cells. Paclitaxel therapy is initiated. This treatment will target which of the following in this patient's tumor?


A. Dihydrofolate reductase
B> Dihydroorotate dehydrogenase
C. DNA polymerase a
D. DNA polymerase 13
E. DNA topoisomerase I
F. DNA topoisomerase II
G. Ribonucleotide reductase
H. RNA polymerase
I. 13-Tubulin