A 29-year old man comes to the physician because of a 1-week history of fever, muscle aches, sore throat, and nonproduct

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A 29-year old man comes to the physician because of a 1-week history of fever, muscle aches, sore throat, and nonproductive cough. His temperature is 38.9°C(102°F).Rhonchi are heard on auscultation of the chest. A chest x-ray shows bronchopneumonia of the right lower lobe. Symptoms persist after 7 days of amoxicillin therapy. A test result for cold agglutinins is positive. Which of the following features of the causal organism best explains the ineffectiveness of the pharmacotherapy in this patient?

A) Absence of peptidoglycan
B) Alteration of penicillin-binding proteins
C) Impermeable outer membrane
D) Production of a 13-lactamase that inactivatesa moxicillin
E) Requirementofsterolsforgrowth