A 12-year-old girl is brought to the physician by her mother after the dentist found many unerupted and supernumerary te

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A 12-year-old girl is brought to the physician by her mother after the dentist found many unerupted and supernumerary teeth. Physical examination shows frontal bossing, hypertelorism, and retained deciduous teeth. When prompted, the patient is able to place her shoulders together anteriorly. Serum studies show a decreased alkaline phosphatase activity. A chest x-ray shows hypoplasia of the clavicles. Skull x-rays show open sutures and multiple Wormian bones. Genetic testing shows a mutation in the CBFA1 gene Which of the following cell types is directly affected by the mutation in this patient?


A) Chondroblasts
B) Chondroclasts
C) Chondrocytes
D) Osteob'asts
E) Osteoclasts
F) Osteocytes