For questions #8 through #10 Consider the data for a number of potential drugs in Fig. 1B below. B CAMP Inhibition (%) F

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For Questions 8 Through 10 Consider The Data For A Number Of Potential Drugs In Fig 1b Below B Camp Inhibition F 1 (152.11 KiB) Viewed 14 times

Fig. 1. (B) Compounds were tested for their ability to stimulatean increase in cytosolic calcium concentrations in cells loadedwith a fluorescent dye. Results are expressed as the fluorescencemaximum count.
8. Which compound is the least potent in this assay, and what isan estimate of its potency? How would you represent its potency?Explain why.
9. (2.5 pts) In Fig. 1B in the previous question, do these drugshave equal potency, equal efficacy, or both equal potency &efficacy? Explain why.
10. (2.5 pts) In Fig. 1B in the previous question, whichcompound could be referred to as a partial agonist? Explainwhy.
For questions #8 through #10 Consider the data for a number of potential drugs in Fig. 1B below. B CAMP Inhibition (%) Fluorescence maximum count 80 70 60 50 40 30 20 10 0. -10 -20 12 30000- 25000- 20000- 15000- 10000- 5000- 0 12 B THE_THE_TIES THE THE $1 10 9 8 7 B 5 agonist (-log M) 4 11 10 9 8 7 6 5 4 agonist (-log M) 2MeSADP ADP ◆ ADPBS A ATP OPTX+2MeSADP 2MeSADP ADP ADPBS A ATP