- Several Different Mutations Within The Gene Shown Below Can Result In A Neurodegenerative Disease Below Is A Drawing Of 1 (62.78 KiB) Viewed 13 times
- Several Different Mutations Within The Gene Shown Below Can Result In A Neurodegenerative Disease Below Is A Drawing Of 2 (62.78 KiB) Viewed 13 times
Several different mutations within the gene shown below can result in a neurodegenerative disease. Below is a drawing of the coding strand of the gene. All exons (represented as boxes) are present in the normal mature mRNA. Transcription starts at the arrow marked TSS. Only known silencer regulatory region A: 5-base deletion TATAA B: 5' splice-site mutation WT TSS I Five mutations labeled A-E on the diagram have been found in this gene. The gel shows mature mRNA from an unaffected individual (labeled "WT"). Each empty lane represents an individual with a mutation in region A, B, C, D, or E. Samples are loaded at the top of the gel. Drag the correct band to its location in each of the 5 lines. A 5² C: 3' splice-site mutation 3 B 5 6 с 7 8 D: Missense mutation 9 E: Nonsense mutation D 10 12 E 13 14 15