Mr. D.F. is a 37 year old Caucasian male who is 5' 7" with a weight of 103 kg, and a BMI of 35.6 kg/m2. 1. Choose an

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Mr. D.F. is a 37 year old Caucasian male who is 5' 7" with a weight of 103 kg, and a BMI of 35.6 kg/m2.
1. Choose an appropriate type of weight to be used in estimated drug dosage. Explain your decision.
2. What other clinical information should be considered in determining dosage?
3. Discuss 2 properties that play a significant role in drug distribution in obese individuals. Be detailed.
4. If Mr. D.F. was administered methylprednisolone, how effective would Mr. D. F.'s hepatic drug clearance be during phase I of the metabolic reaction. What causes this?
5. Why is drug clearance in the kidneys generally increased in obese patients?