For an active metabolite of a drug that has formation rate-limited pharmacokinetics, the elimination half-life of this m

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For an active metabolite of a drug that has formationrate-limited pharmacokinetics, the elimination half-life of thismetabolite is most accurately estimated.... For an activemetabolite of a drug that has formation rate-limitedpharmacokinetics, the elimination half-life of this metabolite ismost accurately estimated.... For an active metabolite of a drugthat has formation rate-limited pharmacokinetics, the eliminationhalf-life of this metabolite is most accurately estimated.... (giveexplanation)
a. Directly from the metabolite concentration-time data after IVadministration of the metabolite
b. Directly from the metabolite concentration-time data after IVadministration of the drug
c. Directly from the drug concentration-time data after IVadministration of the drug
d. Indirectly using feathering of the metabolite concentration-time data after IV administration of the metabolite e. Indirectlyusing feathering of the drug concentration-time data after IVadministration of the drug