According to 23andme.com: hereditary fructose intolerance is arare genetic disorder characterized by low blood sugar levels,stomach pain, and vomiting after after eating fructose. Hereditaryfructose intolerance is caused by variants in the ALDOB gene, whichproduces an enzyme found mainly in the liver, where it helps tobreak down the sugar frucotse. Certain variants in ALDOB disruptenzyme function, resulting in harmful buildup of fructosebyproducts in liver cells. A person must be homozygous for variantALDOB alleles to have the condition. 0.90% of Eurpoeans carry onevariant SNP that disrupts ALDOB function.
According To 23andme Com Hereditary Fructose Intolerance Is A Rare Genetic Disorder Characterized By Low Blood Sugar Le 1 (111.62 KiB) Viewed 17 times
a) calculate the probability that 2 south asian people who candigest fructose will have a child with hereditary fructoseintolerance.
A149P Gene: ALDOB Marker: rs1800546 Chromosome 9 с Typical copy from one of your parents ▬▬● с X³ Gene: ALDOB ●-● ●-● Typical copy from your other parent ^ Biological explanation The variant tested is a change from a C to a G in the DNA sequence of the ALDOB gene. It results in a form of the enzyme that is less stable and less active. This variant is also called A150P. ^ Typical vs. variant DNA sequence(s) Typical Sequence Substitution Variant: G European African American Ashkenazi Jewish Hispanic or Latino South Asian Percent of 23andMe customers with variant G Variant Sequence 0.90% ( 0.30% 0.44% 0.70% <0.05%
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