- I Need Help With This Study Guide 1 (243.05 KiB) Viewed 29 times
1. Explain how a biotransformation reaction can enhance the elimination of a foreign compound 2. For any given functional group within a drug molecule provided in the class slides, identify the possible types of metabolic transformations that it could undergo. 3. For each Phase I metabolic transformation, draw key intermediates and/or the final metabolic product. 4. For each Phase II metabolic transformation, draw and/or identify the activated intermediate, identify the transferring enzyme, identify the functional groups that can be conjugated by this path, and/or identify any deconjugating enzymes 5. List factors that affect drug metabolism 6. Define first pass effect 7. Define the P-glycoprotein pump and explain how it can effect drug bioavailability 8. Compare and contrast induction and inhibition of CYP450 metabolism 9. What is the most metabolism 7 2 1 1 4 common type of phase I metabolism and provide an example of this type of 1127 m 2 40 2000 120 141013