Haemochromatosis is a recessive disorder caused by mutations in the HFE gene. The disorder can be the result of nonfunct

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Haemochromatosis Is A Recessive Disorder Caused By Mutations In The Hfe Gene The Disorder Can Be The Result Of Nonfunct 1 (28.59 KiB) Viewed 37 times

Haemochromatosis is a recessive disorder caused by mutations in the HFE gene. The disorder can be the result of nonfunctional HFE protein, or from very low levels (expression) of the HFE protein. Below is a northern blot gel showing the amount and size of HFE mRNA for a person who does not have haemochromatosis (WT). The mRNA was loaded at the top of the gel. WT A Position the bands on the gel shown in each question as directed. Janine has an out-of-frame 200-bp insertion mutation in an exon that leads to the mRNA transcript containing an early stop codon. Her HFE protein is shorter than WT. Position Janine's band in Lane D. WT B Given responses: A B C D L