A researcher conducts a screen of chemical inhibitors of the novel receptor R166. R166 is a large protein complex made u

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A researcher conducts a screen of chemical inhibitors of the novel receptor R166.
R166 is a large protein complex made up of 3 protein subunits, a, b and c. When all 3 subunits are together, R166 is inactive. When
acuvated, Subunit b dissociates from a and c
1. How would you go about to obtain the structure of R166?
2. After you conducted chemical screening with the structure of R166, you identified 20 compounds that seems to bind to R166. How would you go about to further narrow down the 20 compounds to one
potential lead compound? Be specific in your answer. What technique or experiment will you carry out? What is the read out of your experiment?