1B. 1c A Hydrolysis His HO CO₂Na OH B CH3 Tetrahedral intermediate CH3 His Carboxylesters are cleaved by carboxylesteras

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1b 1c A Hydrolysis His Ho Co Na Oh B Ch3 Tetrahedral Intermediate Ch3 His Carboxylesters Are Cleaved By Carboxylesteras 1 (303.8 KiB) Viewed 81 times

1B. 1c A Hydrolysis His HO CO₂Na OH B CH3 Tetrahedral intermediate CH3 His Carboxylesters are cleaved by carboxylesterases via the addition of water to form an alcohol and an acid metabolite. The image represents the concluding steps in the hydrolysis reaction of a hypothetical carboxylester, leading to the formation of an acid metabolite. Observe the image and answer the following questions: (a) If water molecule is omitted from this reaction, what will be the effect on the reaction? Explain. (b) If histidine is substituted by (a)lysine or (b)phenylalanine, which would reduce the efficiency of the reaction? OH R₂ Acid Metabolite 2 OH-N Given here is the structure of a fluvastatin drug molecule. Answer the following questions, with valid explanations: (a) Is the drug soluble in water? Can it form ionic bonds? (b) (c) Can it form covalent bonds? (d) Whether the drug is lipophilic?