Question 27 The following pharmacokinetic data for N-acetylprocainamide (NAPA) were obtained in a Phase 1 study in volun

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Question 27 The Following Pharmacokinetic Data For N Acetylprocainamide Napa Were Obtained In A Phase 1 Study In Volun 1 (45.21 KiB) Viewed 77 times

Question 27 The following pharmacokinetic data for N-acetylprocainamide (NAPA) were obtained in a Phase 1 study in volunteers with normal kidney function: • Elimination half-life: 6.2 h. • Elimination clearance: 233 mL/min. • % Renal excretion: 75.8% Estimate the elimination clearance of NAPA that would be expected for a patient with a creatinine clearance of 50 mL/min. Assume that a creatinine clearance of 100 mL/min is the value for individuals with normal kidney function. 8.7 L/h 5.3 L/h 7.0 L/h 1 pts 17.4 L/h 28 L/h