Summarize the currents that are mediated when acetylcholine is
applied to a muscle cell that is voltage clamped at -60 mM, 0 mV,
and +60 mV. Also indicate the ion flux that is mediating these
currents.
Gamma-amino butyric acid (GABA)-gated ion channels are generally
inhibitory and are selective for Cl- ions. GABA is also able to
active the GABAb receptor, a G-protein coupled receptor
(GPCR), which ultimately results in opening of potassium-selective
channels. What effect does GABA have on neurons that express the
GABA-gated ion channel and the GABAb GPCR?
What effect does a reduction in extracellular calcium have on
synaptic transmission?
What is one criteria required to establish a small molecule or
peptide functions as a neurotransmitter? Summarize an experiment
that could be used to support a newly discovered small molecule is
a neurotransmitter.
Neurotransmission has been referred to as a “quantal” process.
In your own words, summarize what is meant by the term quantal?
Starting with a blank piece of paper, draw a synapse and diagram
how an electrical signal in a presynaptic cell is covered into a
chemical signal results in an electrical signal in the postsynaptic
cell.
Summarize the currents that are mediated when acetylcholine is applied to a muscle cell that is voltage clamped at -60 m
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